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Qdots have a band gap that depends on a complicated fashion upon a number of factors, including size of particle, bond type, and bond strength 23. Generally, a Qdot is composed of approximately 100 to 10,000 atoms 1—30 nm, and has optical properties distinct from its bulk counterpart Fig.

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It has been reported that natural antibodies are present in the body against these proteins, probably to clear the metabolites of collagen and damaged autologus albumin 72,73. However, a small percentage of the pop- ulation is allergic to certain proteins such as gelatin, where an immediate hyper- sensitivity reaction mediated by IgE and in some cases delayed hypersensitivity reactions have been observed 74.

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