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This information is intended for use by Sitagliptin low price professionals 1. Qualitative and quantitative composition Each 25 mg tablet contains sitagliptin phosphate monohydrate, equivalent to 25 mg sitagliptin. Each 50 mg tablet contains sitagliptin phosphate monohydrate, equivalent to 50 mg sitagliptin. Each 100 mg tablet contains sitagliptin phosphate monohydrate, equivalent to 100 mg sitagliptin. For the full list of excipients, see section 6.
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Pharmaceutical Sitagliptin low price 25 mg tablet: Clinical particulars For adult patients with type 2 diabetes mellitus, Januvia is indicated to improve glycaemic control: Januvia is also indicated as Sitagliptin low price to insulin with or without metformin when diet and exercise plus stable dose of insulin do not provide adequate glycaemic control. When Januvia is used in combination with a sulphonylurea or with insulin, a lower dose of the sulphonylurea or insulin may be considered to reduce the risk of hypoglycaemia see section 4. If a dose of Januvia is missed, Sitagliptin Lowest Price, it should be taken as soon as the patient remembers. A double dose should not be taken on the same day.
- Elderly No dose adjustment is necessary based on age.
- When considering the use of sitagliptin in combination with another anti-diabetic medicinal product, its conditions for use in patients with renal impairment should be checked.
Special populations Renal impairment When considering the use of sitagliptin in tlccmiracle.org with another anti-diabetic medicinal product, its conditions for use in patients with renal impairment should be checked. Because there is a dosage adjustment based upon renal Sitagliptin low price, assessment of renal function is recommended prior to initiation of Januvia and periodically thereafter. Hepatic Sitagliptin low price No dose adjustment is necessary for patients with mild to moderate hepatic impairment. Januvia has not been studied in patients with severe hepatic impairment and care should be exercised see section 5. However, because sitagliptin is primarily renally eliminated, severe hepatic impairment is not expected to affect the pharmacokinetics of sitagliptin.
Elderly No dose adjustment is necessary based on age.
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Paediatric population The safety and efficacy of sitagliptin in children and adolescents under 18 years of age have not yet been established. No data are available. Acute pancreatitis Use of DPP-4 inhibitors has been associated with a risk of developing acute pancreatitis. Patients should be informed of the characteristic symptom of acute pancreatitis: If pancreatitis is suspected, Januvia and other potentially suspect medicinal products should be discontinued; if acute pancreatitis is confirmed, Sitagliptin Lowest Price, Januvia should not be restarted.
Caution should be Generique Du Trecator Sc in Sitagliptin low prices with a history of pancreatitis. Hypoglycaemia when used in combination with other anti-hyperglycaemic medicinal products In clinical trials of Januvia as monotherapy and as part of combination therapy with medicinal products not known to cause hypoglycaemia i. Hypoglycaemia has been observed when sitagliptin was used in combination with insulin or a sulphonylurea. Therefore, to reduce the risk of hypoglycaemia, a lower dose of sulphonylurea or insulin may be considered see section 4. Renal impairment Sitagliptin is renally excreted. When considering the use of sitagliptin in Sitagliptin low price with another anti-diabetic medicinal product, its conditions for use in patients with renal impairment should be checked.
Hypersensitivity reactions Post-marketing reports of serious hypersensitivity reactions in patients treated with sitagliptin have been reported. These reactions include anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome. Onset of these reactions occurred within the first 3 months after initiation of treatment, with some reports occurring after the first dose. If a hypersensitivity reaction is suspected, Januvia should be discontinued.
Other Sitagliptin low price causes for the event should be assessed, and alternative treatment for diabetes initiated. Bullous pemphigoid There have been post-marketing reports of bullous pemphigoid in patients taking DPP-4 inhibitors including sitagliptin. If bullous pemphigoid is suspected, Januvia should be discontinued.
In patients with normal renal function, metabolism, Sitagliptin Lowest Price, including via CYP3A4, plays only a small role in the clearance of sitagliptin.
Metabolism may play a more significant role in the elimination of sitagliptin in the Sitagliptin low price of severe renal impairment or end-stage renal disease ESRD. For this reason, Sitagliptin Lowest Price, it is possible that potent CYP3A4 inhibitors i. The effect of potent CYP3A4 inhibitors in the setting of renal impairment has not been assessed in a clinical Sitagliptin low price. In vitro transport studies showed that sitagliptin is a substrate for p-glycoprotein and organic anion transporter-3 OAT3. OAT3 mediated transport of sitagliptin was inhibited in vitro by probenecid, although the risk of clinically meaningful interactions is considered to be low.
A study was cheap Levitra Soft to assess the Sitagliptin low price of ciclosporin, a potent inhibitor of p-glycoprotein, on the pharmacokinetics of sitagliptin, Sitagliptin Lowest Price. These changes in sitagliptin pharmacokinetics were not considered to be clinically meaningful. The renal clearance of sitagliptin was not meaningfully altered. Therefore, meaningful interactions would not be expected with other p-glycoprotein inhibitors.
Effects of sitagliptin on other medicinal products Digoxin: Sitagliptin had a small effect on plasma digoxin concentrations. No dose adjustment of digoxin is recommended. In vitro data suggest that sitagliptin does not inhibit nor induce CYP450 isoenzymes.
Januvia (100mg) (Sitagliptin) Drug Price and Information
In clinical studies, sitagliptin did not meaningfully alter the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, warfarin, or oral contraceptives, providing in vivo evidence of a low propensity for causing interactions with Sitagliptin low prices of CYP3A4, CYP2C8, CYP2C9, and organic cationic transporter OCT. Sitagliptin may be a mild inhibitor buy Sildigra p-glycoprotein in vivo. Studies in animals have shown reproductive toxicity at high doses see section 5. The Sitagliptin low price risk for humans is unknown. Due to lack of human data, Januvia should not be used during pregnancy. Breast-feeding It is unknown whether sitagliptin is excreted in human breast milk.
Animal studies have shown excretion of sitagliptin in breast milk. Januvia should not be used during breast-feeding. Fertility Animal data do not suggest an effect of treatment with sitagliptin on male and female fertility. Human data are lacking. However, Sitagliptin low price driving or using machines, it should be taken into account that dizziness and somnolence have been reported. In addition, patients should be alerted to the risk of hypoglycaemia when Januvia is used in combination with a sulphonylurea or with insulin. Hypoglycaemia has been reported in Sitagliptin low price with sulphonylurea 4. Tabulated list of adverse reactions Adverse reactions are listed below Table 1 by system organ class and frequency. Frequencies are defined as: The frequency of adverse reactions identified from placebo-controlled clinical studies of sitagliptin monotherapy and post-marketing experience Adverse reaction Blood and lymphatic system disorders thrombocytopenia.